Ku80 Antibody / XRCC5
The protein encoded by the XRCC5 gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V (D) J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V (D) J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [RefSeq]
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1:5000-1:10000
UniProt
P13010
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human Ku80 / XRCC5 was used as the immunogen for the Ku80 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
FAE-24
Type
Recombinant
Applications
WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the Ku80 antibody at -20oC.
Limitations
This Ku80 antibody is available for research use only.
Storage Conditions
Store the Ku80 antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the Ku80 antibody should be determined by the researcher.
Image Legend
Western blot testing of human HeLa cell lysate with Ku80 antibody. Predicted molecular weight ~80 kDa.
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