NF-H Antibody / Neurofilament Heavy
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. The NEFH gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [RefSeq]
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1:500-1:2000
UniProt
P12036
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human Neurofilament Heavy / NF-H / NEFH was used as the immunogen for the NF-H antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
AOEO-14
Type
Recombinant
Applications
WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the NF-H antibody at -20oC.
Limitations
This NF-H antibody is available for research use only.
Storage Conditions
Store the NF-H antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the NF-H antibody should be determined by the researcher.
Image Legend
Western blot testing of human brain lysate with NF-H antibody. Predicted molecular weight ~200 kDa.
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