CDK4 Antibody
The protein encoded by the CDK4 gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16 (INK4a) . This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb) . Mutations in this gene as well as in its related proteins including D-type cyclins, p16 (INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [RefSeq]
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1:1000-1:2000
UniProt
P11802
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human CDK4 was used as the immunogen for the CDK4 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
HOB-3
Type
Recombinant
Applications
WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the CDK4 antibody at -20oC.
Limitations
This CDK4 antibody is available for research use only.
Storage Conditions
Store the CDK4 antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the CDK4 antibody should be determined by the researcher.
Image Legend
Western blot testing of human HeLa cell lysate with CDK4 antibody. Predicted molecular weight ~34 kDa.
Frequently Asked Questions
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