Ubiquitin Antibody
The UBB gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. [RefSeq]
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1:1000-1:2000, Immunohistochemistry (FFPE) : 1:50-1:250
UniProt
P0CG47
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human Ubiquitin / UBB was used as the immunogen for the Ubiquitin antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
DIG-21
Type
Recombinant
Applications
IHC-P, WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the Ubiquitin antibody at -20oC.
Limitations
This Ubiquitin antibody is available for research use only.
Storage Conditions
Store the Ubiquitin antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the Ubiquitin antibody should be determined by the researcher.
Location
Cytoplasmic, nuclear
Image Legend
Western blot testing of human 293T cell lysate with Ubiquitin antibody.
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