CYP3A4 Antibody / Cytochrome P450 3A4
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide.
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1:1000-1:5000
UniProt
P08684
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human Cytochrome P450 3A4 / CYP3A4 was used as the immunogen for the CYP3A4 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
ACDE-3
Type
Recombinant
Applications
WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the CYP3A4 antibody at -20oC.
Limitations
This CYP3A4 antibody is available for research use only.
Storage Conditions
Store the CYP3A4 antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the CYP3A4 antibody should be determined by the researcher.
Image Legend
Western blot testing of human fetal liver lysate with CYP3A4 antibody. Expected molecular weight: 50-57 kDa.
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