C-Met Antibody / MET / HGFR

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. [RefSeq]

Product Specifications

CAS Number

9000-83-3

Specifications

Western blot: 1:500-1:2000, Immunohistochemistry (FFPE) : 1:50-1:200, Immunofluorescence: 1:50-1:200

UniProt

P08581

Host

Rabbit

Reactivity

Human

Immunogen

A synthetic peptide specific to human c-Met / MET was used as the immunogen for the c-Met antibody.

Clonality

Monoclonal

Isotype

IgG

Clone

BFA-13

Type

Recombinant

Applications

IHC-P, WB, IF

Purity

Affinity purified

Format

Purified

Buffer

Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA

Reconstitution

Store the c-Met antibody at -20oC.

Limitations

This c-Met antibody is available for research use only.

Storage Conditions

Store the c-Met antibody at -20°C.

Formulation

Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA

Applications Notes

Optimal dilution of the c-Met antibody should be determined by the researcher.

Image Legend

IHC staining of FFPE human stomach tissue with c-Met antibody. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.