MDR1 Antibody / P Glycoprotein / ABCB1
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [RefSeq]
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1:500-1:2000
UniProt
P08183
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human P Glycoprotein / ABCB1 / MDR1 was used as the immunogen for the MDR1 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
FDB-1
Type
Recombinant
Applications
WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the MDR1 antibody at -20oC.
Limitations
This MDR1 antibody is available for research use only.
Storage Conditions
Store the MDR1 antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the MDR1 antibody should be determined by the researcher.
Image Legend
Western blot testing of human HeLa cell lysate with MDR1 antibody. Expected molecular weight: 141-180 kDa depending on glycosylation level.
Documents
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
