ERCC1 Antibody
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. [RefSeq]
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1:500-1:2000
UniProt
P07992
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human ERCC1 was used as the immunogen for the ERCC1 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
AOFA-5
Type
Recombinant
Applications
WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the ERCC1 antibody at -20oC.
Limitations
This ERCC1 antibody is available for research use only.
Storage Conditions
Store the ERCC1 antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the ERCC1 antibody should be determined by the researcher.
Image Legend
Western blot testing of human HeLa cell lysate with ERCC1 antibody. Predicted molecular weight ~36 kDa.
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