CD141 Antibody / Thrombomodulin
The protein encoded by the intronless THBD gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [RefSeq]
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1:500-1:2000, Immunohistochemistry (FFPE) : 1:50-1:200
UniProt
P07204
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human Thrombomodulin / CD141 was used as the immunogen for the CD141 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
COO-20
Type
Recombinant
Applications
IHC-P, WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the CD141 antibody at -20oC.
Limitations
This CD141 antibody is available for research use only.
Storage Conditions
Store the CD141 antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the CD141 antibody should be determined by the researcher.
Location
Cell membrane, cytoplasmic
Image Legend
Western blot testing of human placenta lysate with CD141 antibody. Expected molecular weight: 60-100 kDa depending on glycosylation.
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