Thyroid Peroxidase Antibody / TPO

The TPO gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA.

Product Specifications

CAS Number

9000-83-3

Specifications

Western blot: 1:500-1:2000

UniProt

P07202

Host

Rabbit

Reactivity

Human

Immunogen

A synthetic peptide specific to human TPO / Thyroid peroxidase was used as the immunogen for the Thyroid Peroxidase antibody.

Clonality

Monoclonal

Isotype

IgG

Clone

AFFI-20

Type

Recombinant

Applications

Purity

Affinity purified

Format

Purified

Buffer

Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA

Reconstitution

Store the Thyroid Peroxidase antibody at -20oC.

Limitations

This Thyroid Peroxidase antibody is available for research use only.

Storage Conditions

Store the Thyroid Peroxidase antibody at -20°C.

Formulation

Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA

Applications Notes

Optimal dilution of the Thyroid Peroxidase antibody should be determined by the researcher.

Image Legend

Western blot testing of human thyroid lysate with Thyroid Peroxidase antibody. Predicted molecular weight ~103 kDa but may be observed at higher molecular weights due to glycosylation.