Rb1 Antibody / Retinoblastoma
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [RefSeq]
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1:1000-1:2000
UniProt
P06400
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human Retinoblastoma / Rb was used as the immunogen for the Rb1 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
FCD-18
Type
Recombinant
Applications
WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the Rb1 antibody at -20oC.
Limitations
This Rb1 antibody is available for research use only.
Storage Conditions
Store the Rb1 antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the Rb1 antibody should be determined by the researcher.
Image Legend
Western blot testing of human 1) Jurkat and 2) MCF7 cell lysate with Rb1 antibody. Predicted molecular weight ~110 kDa.
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