Insulin Receptor Antibody
The INSR gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [RefSeq]
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1:1000-1:2000, Immunofluorescence: 1:50-1:200
UniProt
P06213
Host
Rabbit
Reactivity
Human, Rat
Immunogen
A synthetic peptide specific to human Insulin Receptor / INSR was used as the immunogen for the Insulin Receptor antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
GGA-9
Type
Recombinant
Applications
WB, IF
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the Insulin Receptor antibody at -20oC.
Limitations
This Insulin Receptor antibody is available for research use only.
Storage Conditions
Store the Insulin Receptor antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the Insulin Receptor antibody should be determined by the researcher.
Image Legend
Western blot testing of human HeLa cell lysate with Insulin Receptor antibody. Expected molecular weight: ~156 kDa (precursor), ~95 kDa (b-subunit) .
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