Keratin 8 Antibody / Cytokeratin 8
The KRT8 gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. [RefSeq]
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1:10000-1:20000, Immunohistochemistry (FFPE) : 1:50-1:200
UniProt
P05787
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human Cytokeratin 8 / KRT8 was used as the immunogen for the Keratin 8 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
CIG-11
Type
Recombinant
Applications
IHC-P, WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the Keratin 8 antibody at -20oC.
Limitations
This Keratin 8 antibody is available for research use only.
Storage Conditions
Store the Keratin 8 antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the Keratin 8 antibody should be determined by the researcher.
Image Legend
Western blot testing of human HaCat cell lysate with Keratin 8 antibody. Predicted molecular weight ~56 kDa.
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