HER2 Antibody / ErbB2
The ERBB2 gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. [RefSeq]
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1:500-1:2000, Immunohistochemistry (FFPE) : 1:50-1:200, Immunofluorescence/Immunocytochemistry: 1:50-1:200
UniProt
P04626
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human HER2 / ErbB2 was used as the immunogen for the HER2 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
BCI-5
Type
Recombinant
Applications
IHC-P, IF/ICC, WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the HER2 antibody at -20oC.
Limitations
This HER2 antibody is available for research use only.
Storage Conditions
Store the HER2 antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the HER2 antibody should be determined by the researcher.
Image Legend
IF/ICC staining of human SK-BR-3 cells with HER2 antibody (green) and DAPI nuclear stain (blue) .
Documents
Frequently Asked Questions
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