Dencichine

Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity.

Product Specifications

CAS Number

[5302-45-4]

Product Name Alternative

Dencichin; ODAP

UNSPSC

12352211

Hazard Statement

H302, H319, H372, H410

Target

HIF/HIF Prolyl-Hydroxylase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Dencichin.html

Concentration

10mM

Purity

99.59

Solubility

0.1 M HCl : 3.33 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 5 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic)

Smiles

N[C@@H](CNC(C(O)=O)=O)C(O)=O

Molecular Formula

C5H8N2O5

Molecular Weight

176.13

Precautions

H302, H319, H372, H410

References & Citations

[1]Eslavath RK, et al. β-N-oxalyl-L-α, β- diaminopropionic acid induces HRE expression by inhibiting HIF-prolyl hydroxylase-2 in normoxic conditions. Eur J Pharmacol. 2016 Nov 15;791:405-411.|[2]Jie L, et al. Dencichine ameliorates kidney injury in induced type II diabetic nephropathy via the TGF-β/Smad signalling pathway. Eur J Pharmacol. 2017 Oct 5;812:196-205.