Dencichine
Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity.
Product Specifications
CAS Number
5302-45-4
Product Name Alternative
Dencichin; ODAP
UNSPSC
12352211
Hazard Statement
H302, H319, H372, H410
Target
HIF/HIF Prolyl-Hydroxylase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Dencichin.html
Concentration
10mM
Purity
99.59
Solubility
0.1 M HCl : 3.33 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 5 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic)
Smiles
N[C@@H](CNC(C(O)=O)=O)C(O)=O
Molecular Formula
C5H8N2O5
Molecular Weight
176.13
Precautions
H302, H319, H372, H410
References & Citations
[1]Eslavath RK, et al. β-N-oxalyl-L-α, β- diaminopropionic acid induces HRE expression by inhibiting HIF-prolyl hydroxylase-2 in normoxic conditions. Eur J Pharmacol. 2016 Nov 15;791:405-411.|[2]Jie L, et al. Dencichine ameliorates kidney injury in induced type II diabetic nephropathy via the TGF-β/Smad signalling pathway. Eur J Pharmacol. 2017 Oct 5;812:196-205.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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