NRAS Antibody
NRAS is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. It has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in the gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [RefSeq]
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1:500-1:2000
UniProt
P01111
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human NRAS was used as the immunogen for the NRAS antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
AOFE-14
Type
Recombinant
Applications
WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the NRAS antibody at -20oC.
Limitations
This NRAS antibody is available for research use only.
Storage Conditions
Store the NRAS antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the NRAS antibody should be determined by the researcher.
Image Legend
Western blot testing of human SH-SY5Y cell lysate with NRAS antibody. Predicted molecular weight ~21 kDa.
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