Bcl10 Antibody
Bcl10 contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. It is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. Bcl10 is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [RefSeq]
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1:1000-1:2000
UniProt
O95999
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human Bcl10 was used as the immunogen for the Bcl10 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
GDB-2
Type
Recombinant
Applications
WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the Bcl10 antibody at -20oC.
Limitations
This Bcl10 antibody is available for research use only.
Storage Conditions
Store the Bcl10 antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the Bcl10 antibody should be determined by the researcher.
Image Legend
Western blot testing of human 1) HeLa and 2) Raji cell lysate with Bcl10 antibody. Expected molecular weight: 26-33 kDa.
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