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Phospho-NBS1 Antibody (pS343)

Nijmegen breakage syndrome protein 1 (NBS1) is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. [UniProt]

Product Specifications

CAS Number

9000-83-3

Specifications

Western blot: 1:500-1:2000

UniProt

O60934

Host

Rabbit

Reactivity

Human

Immunogen

A synthetic peptide specific to human NBS1 / NBN (surrounding pS343) was used as the immunogen for the phospho-NBS1 antibody.

Clonality

Monoclonal

Isotype

IgG

Clone

BGI-14

Type

Recombinant

Applications

WB

Purity

Affinity purified

Format

Purified

Buffer

Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA

Reconstitution

Store the phospho-NBS1 antibody at -20oC.

Limitations

This phospho-NBS1 antibody is available for research use only.

Storage Conditions

Store the phospho-NBS1 antibody at -20°C.

Formulation

Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA

Applications Notes

Optimal dilution of the phospho-NBS1 antibody should be determined by the researcher.

Image Legend

Western blot testing of etoposide-treated human Jurkat cell lysate with phospho-NBS1 antibody. Predicted molecular weight ~95 kDa.

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