PRC1 Antibody
Protein regulator of cytokinesis 1 (PRC1) is a key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression. [UniProt]
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1:500-1:2000
UniProt
O43663
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human PRC1 was used as the immunogen for the PRC1 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
EH-16
Type
Recombinant
Applications
WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the PRC1 antibody at -20oC.
Limitations
This PRC1 antibody is available for research use only.
Storage Conditions
Store the PRC1 antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the PRC1 antibody should be determined by the researcher.
Image Legend
Western blot testing of human HeLa cell lysate with PRC1 antibody. Expected molecular weight ~70-80 kDa, may be observed as a doublet.
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