CRM1 Antibody / XPO1 / Exportin 1
Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP) . Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins.
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1:500-1:2000
UniProt
O14980
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide specific to human CRM1 / XPO1 was used as the immunogen for the CRM1 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
AEFD-24
Type
Recombinant
Applications
WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the CRM1 antibody at -20oC.
Limitations
This CRM1 antibody is available for research use only.
Storage Conditions
Store the CRM1 antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the CRM1 antibody should be determined by the researcher.
Image Legend
Western blot testing of human HeLa cell lysate with CRM1 antibody. Predicted molecular weight ~123 kDa.
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