IGF2BP3 Antibody
RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs) . This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. [UniProt]
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1:500-1:2000
UniProt
O00425
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human Insulin-like growth factor 2 mRNA-binding protein 3 was used as the immunogen for the IGF2BP3 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
AEDB-9
Type
Recombinant
Applications
WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the IGF2BP3 antibody at -20oC.
Limitations
This IGF2BP3 antibody is available for research use only.
Storage Conditions
Store the IGF2BP3 antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the IGF2BP3 antibody should be determined by the researcher.
Image Legend
Western blot testing of human HeLa cell lysate with IGF2BP3 antibody. Predicted molecular weight ~64 kDa.
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