CCL2 Antibody / MCP1
Monocyte chemoattractant protein-1 (MCP-1), a member of the chemokine (chemotactic cytokine) family, is a potent monocyte agonist that is upregulated by oxidized lipids. MCP-1 is also known as CCL2, SCYA2, MCAF. MCAF is a member of family of factors involved in immune and inflammatory responses. The amino acid sequence deduced from the nucleotide sequence reveals the primary structure of the MCAF precursor to be composed of a putative signal peptide sequence of 23 amino acid residues and a mature MCAF sequence of 76 amino acid residues. MCP-1 plays a unique and crucial role in the initiation of atherosclerosis and may provide a new therapeutic target in this disorder. Human MCP-1 is a 8.7KDa non-glycoprotein, consisting of 99 amino acids in precursor form and 76 amino acids in mature form.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, ELISA (Capture) : 1-5 µg/mL (recombinant rat protein)
UniProt
P14844
Host
Rabbit
Reactivity
Rat
Immunogen
Amino acids Q24-R96 from the rat protein were used as the immunogen for the CCL2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, ELISA (Capture)
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
Limitations
This CCL2 antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the CCL2 antibody should be determined by the researcher.
Image Legend
Western blot testing of rat pancreas with CCL2 antibody at 0.5ug/ml. Expected molecular weight ~11 kDa (precursor), ~9 kDa (mature) .
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