CD137 Antibody / 4-1BB
CD137 is a member of the tumor necrosis factor (TNF) receptor family. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, ELISA (Capture) : 1-5 µg/mL (mouse recombinant protein)
UniProt
P20334
Host
Rabbit
Reactivity
Mouse
Immunogen
Amino acids V24-L187 from the mouse protein were used as the immunogen for the CD137 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, ELISA (Capture)
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
Limitations
This CD137 antibody is available for research use only.
Storage Conditions
Product Datasheet
https://www.nsjbio.com/tds-pdf/cd137-antibody-4-1bb-rq4615
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the CD137 antibody should be determined by the researcher.
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