CD137 Antibody / 4-1BB

CD137 is a member of the tumor necrosis factor (TNF) receptor family. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 0.5-1 µg/mL, ELISA (Capture) : 1-5 µg/mL (mouse recombinant protein)

UniProt

P20334

Host

Rabbit

Reactivity

Mouse

Immunogen

Amino acids V24-L187 from the mouse protein were used as the immunogen for the CD137 antibody.

Clonality

Polyclonal

Isotype

IgG

Applications

WB, ELISA (Capture)

Purity

Antigen affinity purified

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide

Reconstitution

After reconstitution, the CD137 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This CD137 antibody is available for research use only.

Storage Conditions

After reconstitution, the CD137 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

Optimal dilution of the CD137 antibody should be determined by the researcher.

Image Legend

Western blot testing on 1ng of mouse recombinant protein with CD137 antibody at 0.5ug/ml. Expected molecular weight: ~30 kDa monomer and 55-60 kDa dimer. Higher molecular weights may be observed due to glycosylation.