TNF alpha Antibody
TNF (Tumor Necrosis Factor alpha) gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, ELISA (Capture) : 1-5 µg/mL (human recombinant protein)
UniProt
P01375
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids V77-L233 from the human protein were used as the immunogen for the TNF alpha antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, ELISA (Capture)
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the TNF alpha antibody should be determined by the researcher.
Image Legend
Western blot testing of human recombinant protein with TNF alpha antibody.
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