ARSA Antibody
Arylsulfatase A (ARSA) is an enzyme that breaks down sulfatides, namely cerebroside 3-sulfate intocerebroside and sulfate. In humans, arylsulfatase A is encoded by the ARSA gene. ARSA is mapped to 22q13.33. The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Flow cytometry: 1-3ug/million cells, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P15289
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids QALKQLQLLKAQLDAAVTFGPSQVARGED were used as the immunogen for the ARSA antibody.
Clonality
Monoclonal
Isotype
IgG2a
Clone
4C10
Applications
FACS, WB, IHC-P
Purity
Protein G affinity
Format
Purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
Limitations
This ARSA antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the ARSA antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
Western blot testing of human 1) A375, 2) A549 and 3) SMMC-7721 lysate with ARSA antibdoy at 0.5ug/ml. Expected molecular weight: 53-63 kDa.
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