NOX4 Recombinant Antibody / NADPH oxidase 4
Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity. [UniProt]
Product Specifications
UniProt
Q9NPH5
Host
Rabbit
Immunogen
A synthetic peptide from human NOX4 was used as the immunogen for the NOX4 antibody.
Clonality
Monoclonal
Isotype
IgG
Type
Recombinant
Applications
WB, IHC-P
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the NOX4 antibody at -20oC.
Limitations
This NOX4 antibody is available for research use only.
CAS Number
9000-83-3
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