Anti-eIF3L/Eif3S6Ip Antibody

Eukaryotic translation initiation factor 3 subunit L ; eIF3l ; Eukaryotic translation initiation factor 3 subunit 6-interacting protein ; Eukaryotic translation initiation factor 3 subunit E-interacting protein ; EIF3L ; EIF3EIP , EIF3S6IP ; HSPC021, HSPC025, MSTP005

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC) . The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426) . .