TPH1 Antibody / Tryptophan Hydroxylase
Tryptophan hydroxylase 1 (TPH1) is an isoenzyme of tryptophan hydroxylase which in humans is encoded by the TPH1 gene. This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, ELISA: 0.1-0.5 µg/mL
UniProt
P17752
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A human partial recombinant protein corresponding to amino acids M1-K111 was used as the immunogen for the TPH1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
Limitations
This TPH1 antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the TPH1 antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) human SGC-7901, 2) rat heart and 3) mouse heart lysate with TPH1 antibody at 0.5ug/ml. Predicted molecular weight ~51 kDa.
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