SPR Antibody / Sepiapterin reductase
Sepiapterin reductase is an enzyme that in humans is encoded by the SPR gene. This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4) . Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Direct ELISA: 0.1-0.5 µg/mL (recombinant human protein) (BSA-free format available)
UniProt
P35270
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A human partial recombinant protein corresponding to amino acids V36-K261 was used as the immunogen for the SPR antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
Limitations
This SPR antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the SPR antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) human HepG2 and 2) mouse HEPA1-6 cell lysate with SPR antibody at 0.5ug/ml. Predicted molecular weight ~28 kDa.
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