TRPC4 Antibody

The short transient receptor potential channel 4 (TRPC4), also known as Trp-related protein 4, is a protein that in humans is encoded by the TRPC4 gene. TRPC4 is a member of the transient receptor potential cation channels. It is mapped to 13q13.3. This protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors andtyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. TRPC4 also has an essential role in endothelial-dependent regulation of vascular tone, endothelial permeability, and neurotransmitter release from thalamic interneurons.

Product Specifications

CAS Number

9007-83-4

Specifications

Western Blot: 0.5-1 µg/mL

UniProt

Q9UBN4

Host

Rabbit

Reactivity

Human

Immunogen

Amino acids MAQFYYKRNVNAPYRDRIPLRIVRAESEL were used as the immunogen for the TRPC4 antibody.

Clonality

Polyclonal

Isotype

IgG

Applications

Purity

Antigen affinity purified

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide

Reconstitution

After reconstitution, the TRPC4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This TRPC4 antibody is available for research use only.

Storage Conditions

After reconstitution, the TRPC4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

Optimal dilution of the TRPC4 antibody should be determined by the researcher.

Prediction Reactivity

Mouse, Rat

Image Legend

Western blot testing of human 1) HeLa, 2) COLO320, 3) MCF7 and 4) 293T cell lysate with TRPC4 antibody at 0.5ug/ml. Predicted molecular weight ~112 kDa, observed here at ~150 kDa.