Kallikrein 1 Antibody
KLK1 (KALLIKREIN 1), also called KLKR, is a protein that in humans is encoded by the KLK1 gene. KLK1 is a member of the peptidase S1 family. KLK1 is a serine protease that generates Lys-bradykinin by specific proteolysis of kininogen-1. The KLK1 gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19 and its exact cytogenetic location is 19q13.33. The KLK1 gene contains 5 coding exons. And KLK1 is the most centromeric gene in the cluster. Mice lacking tissue kallikrein are unable to generate significant levels of kinins in most tissues and develop cardiovascular abnormalities early in adulthood despite normal blood pressure. The protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.
Product Specifications
CAS Number
9007-83-4
Specifications
Western Blot: 0.5-1 µg/mL, ELISA (Capture) : 0.1-0.5 µg/mL
UniProt
P06870
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant human partial protein corresponding to amino acids I25-S262 was used as the immunogen for the Kallikrein 1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
Limitations
This Kallikrein 1 antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Kallikrein 1 antibody should be determined by the researcher.
Image Legend
Western blot testing of 1ng of recombinant human protein with Kallikrein 1 antibody at 0.5ug/ml.
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