CNGB3 Antibody
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. Cyclic nucleotide-gated cation channel beta-3 can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity) . Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. [UniProt]
Product Specifications
CAS Number
9007-83-4
Specifications
IHC (FFPE) : 2-4 µg/mL, ELISA (peptide) LOD: 1:8000
UniProt
Q9NQW8
Host
Goat
Reactivity
Human
Immunogen
Amino acids ESDDKPTEHYYR were used as the immunogen for this CNGB3 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC-P, ELISA (peptide)
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide
Reconstitution
Aliquot and store the CNGB3 antibody at -20oC.
Limitations
This CNGB3 antibody is available for research use only.
Storage Conditions
Aliquot and store the CNGB3 antibody at -20°C.
Formulation
0.5 mg/mL in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide
Applications Notes
Optimal dilution of the CNGB3 antibody should be determined by the researcher.
Image Legend
IHC testing of FFPE human retinal with CNGB3 antibody at 2ug/ml. Staining of the pigmented epithelial cells is seen.
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