CYP2D6 Antibody
CYP2D6, a member of the cytochrome P450 mixed-function oxidase system, is one of the most important enzymes involved in the metabolism of xenobiotics in the body. In particular, CYP2D6 is responsible for the metabolism and elimination of approximately 25% of clinically used drugs, via the addition or removal of certain functional groups – specifically, hydroxylation, demethylation, and dealkylation – at various points along a substrate's core structure. This enzyme also metabolizes several endogenous substances, such as hydroxytryptamines, neurosteroids, and both m-tyramine and p-tyramine which CYP2D6 metabolizes into dopamine in the brain and liver. [Wiki]
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1-3 µg/mL, ELISA (peptide) LOD: 1:1000
UniProt
P10635
Host
Goat
Reactivity
Human
Immunogen
Amino acids PTGQPRPSHH were used as the immunogen for this CYP2D6 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA (peptide)
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide
Reconstitution
Aliquot and store the CYP2D6 antibody at -20oC.
Limitations
This CYP2D6 antibody is available for research use only.
Storage Conditions
Aliquot and store the CYP2D6 antibody at -20°C.
Formulation
0.5 mg/mL in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide
Applications Notes
Optimal dilution of the CYP2D6 antibody should be determined by the researcher.
Image Legend
Western blot testing of human liver lysate with CYP2D6 antibody at 2ug/ml. Predicted molecular weight ~56 kDa.
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