YNT-185 (dihydrochloride)

YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models[1][2].

Product Specifications

CAS Number

[1804978-82-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Orexin Receptor (OX Receptor)

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ynt-185-dihydrochloride.html

Purity

99.78

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=[S](NC1=CC(NCCNC(C(C=CC=C2)=C2N(C)C)=O)=CC=C1)(C(C=C(C3=CC(C(N(C)C)=O)=CC=C3)C=C4)=C4OC)=O.Cl.Cl

Molecular Formula

C33H39Cl2N5O5S

Molecular Weight

688.66

Precautions

H302, H315, H319, H335

References & Citations

[1]Nagahara T, et al. Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists. J Med Chem. 2015;58 (20) :7931-7937.|[2]Irukayama-Tomobe Y, et al. Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models. Proc Natl Acad Sci U S A. 2017;114 (22) :5731-5736.