CCR5 Antibody
Human CC chemokine receptor 5 (CCR5), which is 17.5 kb from the CMKBR2 gene, encodes a 352-amino acid protein with a calculated molecular mass of 40,600 Da. It is organized into four exons and two introns. Human CCR5 is a co-receptor for macrophage-tropic strains of human immunodeficiency virus (HIV) -1 and is expressed by bone-marrow-derived cells. CCR5 is expressed on neurons, astrocytes, and microglia in the central nervous system, and on epithelium, endothelium, vascular smooth muscle and fibroblasts in other tissues. Functionally, CCR5 mediates the activation of cells by the chemokines macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, and RANTES, and serves as a fusion cofactor for macrophage-tropic strains of human immunodeficiency virus type 1.
Product Specifications
CAS Number
9007-83-4
Specifications
Western Blot: 0.5-1 µg/mL
UniProt
P51681
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids YSGILKTLLRCRNEKKRHRAVRLIFT from the human protein were used as the immunogen for the CCR5 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
Limitations
This CCR5 antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the CCR5 antibody should be determined by the researcher.
Image Legend
Western blot testing of human 1) Jurkat and 2) MCF7 cell lysate with CCR5 antibody at 0.5ug/ml. Predicted molecular weight ~41 kDa.
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