Recombinant ITK (352-620) Protein

<strong>Recombinant ITK (352-620) Protein</strong>_x000D_ <strong>Catalog number:</strong> B2017560_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 10 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 31.8 kDa_x000D_ <strong>Supplied as:</strong> SOLUTION_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> IL-2 Inducible T-Cell Kinase, Tyrosine-Protein Kinase LYK, EMT, LYK, LPFS1_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Qi Q, August A. Keeping the (kinase) party going: SLP-76 and ITK dance to the beat Sci STKE. 2007 Jul 24;2007(396):pe39._x000D_ 2: Hussain A, Yu L, Faryal R, Mohammad DK, Mohamed AJ, Smith CI. TEC family kinases in health and disease--loss-of-function of BTK and ITK and the gain-of-function fusions ITK-SYK and BTK-SYK FEBS J. 2011 Jun;278(12):2001-10._x000D_ 3: Raab M, Cai YC, Bunnell SC, Heyeck SD, Berg LJ, Rudd CE. p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8891-5._x000D_ 4: Devkota S, Joseph RE, Boyken SE, Fulton DB, Andreotti AH. An Autoinhibitory Role for the Pleckstrin Homology Domain of Interleukin-2-Inducible Tyrosine Kinase and Its Interplay with Canonical Phospholipid Recognition Biochemistry. 2017 Jun 13;56(23):2938-2949._x000D_ 5: Bunnell SC, Diehn M, Yaffe MB, Findell PR, Cantley LC, Berg LJ. Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade J Biol Chem. 2000 Jan 21;275(3):2219-30._x000D_ 6: Hallumi E, Shalah R, Lo WL, Corso J, Oz I, Beach D, Wittman S, Isenberg A, Sela M, Urlaub H, Weiss A, Yablonski D. Itk Promotes the Integration of TCR and CD28 Costimulation through Its Direct Substrates SLP-76 and Gads J Immunol. 2021 May 15;206(10):2322-2337._x000D_ 7: Brazin KN, Mallis RJ, Fulton DB, Andreotti AH. Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1899-904._x000D_ 8: Bunnell SC, Henry PA, Kolluri R, Kirchhausen T, Rickles RJ, Berg LJ. Identification of Itk/Tsk Src homology 3 domain ligands J Biol Chem. 1996 Oct 11;271(41):25646-56._x000D_ 9: Bach MP, Hug E, Werner M, Holch J, Sprissler C, Pechloff K, Zirlik K, Zeiser R, Dierks C, Ruland J, Jumaa H. Premature terminal differentiation protects from deregulated lymphocyte activation by ITK-Syk J Immunol. 2014 Feb 1;192(3):1024-33._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/11581171">10: Perez-Villar JJ, O'Day K, Hewgill DH, Nadler SG, Kanner SB. Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin alpha (Rch1alpha) Int Immunol. 2001 Oct;13(10):1265-74. </a>_x000D_ _x000D_ <strong>Products Related to Recombinant ITK (352-620) Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>