BRMS1 Antibody

Breast cancer metastasis-suppressor 1 is a protein that in humans is encoded by the BRMS1 gene. This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC) . The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 0.5-1 µg/mL

UniProt

Q9HCU9

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Amino acids D52-D244 from the human protein were used as the immunogen for the BRMS1 antibody.

Clonality

Polyclonal

Isotype

IgG

Applications

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide

Reconstitution

After reconstitution, the BRMS1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This BRMS1 antibody is available for research use only.

Storage Conditions

After reconstitution, the BRMS1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

Optimal dilution of the BRMS1 antibody should be determined by the researcher.

Image Legend

Western blot testing of 1) rat kidney, 2) rat liver, 3) mouse liver and 4) human HeLa lysate with BRMS1 antibody at 0.5ug/ml. Predicted molecular weight ~28 kDa, often observed at ~35 kDa.