CDR2 Antibody
Cerebellar degeneration-related protein 2 is a protein that in humans is encoded by the CDR2 gene. By a combination of study of rodent/human somatic cell hybrids and in situ hybridization, this gene is assigned to 16p13.1-p12. The onconeuronal cerebellar degeneration-related antigen Cdr2 is associated with paraneoplastic syndromes. Neoplastic expression of Cdr2 in ovary and breast tumors triggers an autoimmune response that suppresses tumor growth by developing tumor immunity, but culminates in cerebellar degeneration when Cdr2-specific immune cells recognize neuronal Cdr2.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
Q01850
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Amino acids 232-2656 (ELEQQLGATGAYRARALELEAEVAEMRQMLQSEH) from the human protein were used as the immunogen for the CDR2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide
Reconstitution
Limitations
This CDR2 antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the CDR2 antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) mouse kidney and 2) human MCF7 lysate with CDR2 antibody at 0.5ug/ml. Expected molecular weight: 52-62 kDa.
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