CNPase Antibody / CNP
2',3'-Cyclic-nucleotide 3'-phosphodiesterase, also known as CNPase, is an enzyme that in humans is encoded by the CNP gene. And this gene is mapped to 17q21.2. CNPase is named for its ability to catalyze the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides. CNPase is thought to play a critical role in the events leading up to myelination. Additionally, CNPase has been demonstrated to inhibit the replication of HIV-1 and other primate lentiviruses by binding the retroviral Gag protein and inhibiting the genesis of nascent viral particles.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
Gene ID
1267
UniProt
P09543
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 142-178 (QYQVVLVEPKTAWRLDCAQLKEKNQWQLSADDLKKLK-human) were used as the immunogen for the CNPase antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
Limitations
This CNPase antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the CNPase antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) rat brain, 2) mouse brain and 3) human HeLa lysate with CNPase antibody at 0.5ug/ml. Predicted molecular weight ~47 kDa.
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