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CNPase Antibody / CNP

2',3'-Cyclic-nucleotide 3'-phosphodiesterase, also known as CNPase, is an enzyme that in humans is encoded by the CNP gene. And this gene is mapped to 17q21.2. CNPase is named for its ability to catalyze the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides. CNPase is thought to play a critical role in the events leading up to myelination. Additionally, CNPase has been demonstrated to inhibit the replication of HIV-1 and other primate lentiviruses by binding the retroviral Gag protein and inhibiting the genesis of nascent viral particles.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 0.5-1 µg/mL

Gene ID

1267

UniProt

P09543

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Amino acids 142-178 (QYQVVLVEPKTAWRLDCAQLKEKNQWQLSADDLKKLK-human) were used as the immunogen for the CNPase antibody.

Clonality

Polyclonal

Isotype

IgG

Applications

WB

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide

Reconstitution

After reconstitution, the CNPase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This CNPase antibody is available for research use only.

Storage Conditions

After reconstitution, the CNPase antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

Optimal dilution of the CNPase antibody should be determined by the researcher.

Image Legend

Western blot testing of 1) rat brain, 2) mouse brain and 3) human HeLa lysate with CNPase antibody at 0.5ug/ml. Predicted molecular weight ~47 kDa.

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