TREX2 Antibody

Three prime repair exonuclease 2 is an enzyme that in humans is encoded by the TREX2 gene. By genomic sequence analysis, the TREX2 gene is mapped to chromosome Xq28. This gene encodes a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 0.5-1 µg/mL

UniProt

Q9BQ50

Host

Rabbit

Reactivity

Human

Immunogen

Amino acids E69-A279 from the human protein were used as the immunogen for the TREX2 antibody.

Clonality

Polyclonal

Isotype

IgG

Applications

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide

Reconstitution

After reconstitution, the TREX2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This TREX2 antibody is available for research use only.

Storage Conditions

After reconstitution, the TREX2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

Differences in protocols and secondary/substrate sensitivity may require the TREX2 antibody to be titrated for optimal performance.

Location

Nuclear

Image Legend

Western blot testing of human 1) HeLa and 2) MCF7 cell lysate with TREX2 antibody at 0.5ug/ml. Predicted molecular weight ~31/26 kDa (isoforms 1/2), observed here at ~37 kDa.