Thrombopoietin Antibody
Thrombopoietin (THPO), also known as megakaryocyte growth and development factor (MGDF), is a protein that in humans is encoded by the THPO gene. Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, ELISA: 0.5-1 µg/mL (human protein tested) ; request BSA-free format for coating
UniProt
P40225
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids S22-R258 from the human protein were used as the immunogen for the Thrombopoietin antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, ELISA (protein)
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
Limitations
This Thrombopoietin antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Differences in protocols and secondary/substrate sensitivity may require the Thrombopoietin antibody to be titrated for optimal performance.
Image Legend
Documents
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Mitocondrial Translational Initiation Factor 3 (MTIF3) (NM_001166261) Human Over-expression Lysate
Human Kappa Light Chain (KLC709), Biotin conjugate, 0.1mg/mL
