ATP Citrate Lyase Antibody / ACL
ATP citrate lyase, aslo known as ACLY, is an enzyme that in animals represents an important step in fatty acid biosynthesis. ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer of apparently identical subunits. The product, acetyl-CoA, in animals serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. It is activated by insulin. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. In plants, ATP citrate lyase generates the acetyl-CoA for cytosolically-synthesized metabolites.
Product Specifications
CAS Number
9007-83-4
Specifications
UniProt
P53396
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids M1-I180 from the human protein were used as the immunogen for the ATP Citrate Lyase antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IF/ICC, FACS
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
Limitations
This ATP Citrate Lyase antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Differences in protocols and secondary/substrate sensitivity may require the ATP Citrate Lyase antibody to be titrated for optimal performance.
Location
Cytoplasmic, nuclear
Image Legend
IHC testing of FFPE human colon cancer tissue with ATP Citrate Lyase antibody at 2ug/ml. HIER: steam sections in pH8 EDTA for 20 min.
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