Osteocalcin Antibody
Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a noncollagenous protein found in bone and dentin. In humans, the osteocalcin is encoded by the BGLAP gene. Its receptor is GPRC6A. It is mapped to 1q22. Osteocalcin may play a role in the body's metabolic regulation and is pro-osteoblastic, or bone-building. It acts as a hormone in the body, causing beta cellsin the pancreas to release more insulin, and at the same time directing fat cells to release the hormone adiponectin, which increases sensitivity to insulin. Also, it may play a role in male fertility. And it is found that picomolar amounts of osteocalcin affected insulin secretion and beta-cell proliferation.
Product Specifications
CAS Number
9007-83-4
Specifications
IHC (FFPE) : 0.5-1 µg/mL, FACS: 1-3ug/10^6 cells
Gene ID
25295
UniProt
P04640
Host
Rabbit
Reactivity
Rat
Immunogen
Amino acids Y50-V99 of the rat protein were used as the immunogen for the Osteocalcin antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
IHC-P, FACS
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
Limitations
This Osteocalcin antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Osteocalcin antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Frequently Asked Questions
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