PINX1 Antibody
PINX1, also known as PIN2 interacting protein 1, is a telomerase inhibitor and a possible tumor suppressor. It is mapped to 8p23. Over-expression of PINX1 results in decreased telomerase activity, telomere shortening, and induction of crisis. Reduction of PINX1 leads to an increase in telomerase activity and elongation of telomeres. PINX1 differs from other proteins that regulate telomere length in that it acts on telomerase while other proteins adjust telomere length without affecting telomerase activity. The PINX1 budding yeast orthologue Gnop1 inhibits telomerase by isolating the uncomplexed TERT protein so that it cannot associate with the telomerase template RNA, which prevents telomerase from being assembled. However, in humans, PINX1 impedes already assembled telomerase.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL
UniProt
Q96BK5
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids DHIKVQVKNNHLGLGATINNEDNWIAHQDD of human PINX1 were used as the immunogen for the PINX1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
Limitations
This PINX1 antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the PINX1 antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) human placenta, 2) HeLa, 3) HUT and 4) Jurkat lysate with PINX1 antibody. Predicted/observed molecular weight ~37 kDa.
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
HIV-1 Tat Interacting Protein, 60kD, CT (HTATIP, HTATIP1, cPLA2-interacting Protein, ESA1, PLIP, TIP60) (MaxLight 550) discontinued
