11β-HSD1-IN-10

11β-HSD1-IN-10 (compound c3a) is a potent 11β-HSD1 inhibitor (IC50=1.8 µM for human) . 11β-HSD1-IN-10 can be used in studies of obesity, hyperglycemia and cognitive impairment[1].

Product Specifications

CAS Number

[849021-37-0]

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

11β-HSD

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/11β-hsd1-in-10.html

Solubility

10 mM in DMSO

Smiles

C1=CC=C2C(=C1)N=C(CC(=O)C3=CC(=CC=C3)C(F)(F)F)O2

Molecular Formula

C16H10F3NO2

Molecular Weight

305.25

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

References & Citations

[1]Naredo-Gonzalez G, et al. Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by 19F-Magnetic Resonance Spectroscopy. Sci Rep. 2022 Sep 29;12 (1) :16268.