GR Antibody / Glucocorticoid receptor / NR3C1

The glucocorticoid receptor (GR, or GCR), also known as NR3C1, is the receptor to which cortisol and other glucocorticoids bind. GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Human recombinant NR3C1 protein (AA 20-199) was used as the immunogen for this GR antibody.

Clonality

Polyclonal

Isotype

IgG

Applications

WB, IHC-P

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide

Reconstitution

After reconstitution, the GR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This GR antibody is available for research use only.

Storage Conditions

After reconstitution, the GR antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

Titration of the GR antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Image Legend

Western blot testing of GR antibody and Lane 1: rat liver; 2: (r) brain; 3: (r) spleen; 4: human placenta; 5: (h) SMMC; 6: mouse HEPA; 7: (m) Neuro-2a; 8: (h) HeLa; 9: (r) PC12; Predicted/Observed size: 91~94KD