MSH2 Antibody

MutS homolog 2 is a protein that in humans is encoded by the MSH2 gene, which is located on chromosome 2. It is a tumor suppressor gene and more specifically a caretaker gene that codes for a DNA mismatch repair (MMR) protein, MSH2 forms a heterodimer with MSH6 to make the human MutS<font face=symbol>a</font> mismatch repair complex. It also dimerizes with MSH3 to form the MutS<font face=symbol>b</font> DNA repair complex. MSH2 is involved in many different forms of DNA repair, including transcription-coupled repair, homologous recombination, and base excision repair. It has been found that it may also be a coactivator of ESR1-dependent gene expression.