RACK1 Antibody

Guanine nucleotide-binding protein subunit beta-2-like 1, also known as RACK1, is a 35kDa protein that in humans is encoded by the GNB2L1 gene. It is mapped to 5q35.3. It is a major component of translating ribosomes, which harbor significant amounts of PKC. This gene can provide a physical and functional link between <a href=../search_result.php?search_txt=pkc>PKC</a> signaling and ribosome activation. GNB2L1/RACK1 is also a mediator of agonist-induced Ca(2+) release. Additionally, it is an essential component of an oxygen-independent mechanism for regulating <a href=../search_result.php?search_txt=hif1a>HIF1A</a> stability. Overexpression of RACK1 and PKC-alpha suppressed <a href=../search_result.php?search_txt=clock>CLOCK</a>-BMAL1 transcriptional activity, and it stimulated phosphorylation of BMAL1 by PKC-alpha in vitro.