Glucocorticoid receptor Antibody / GR / NR3C1

The glucocorticoid receptor (GR, or GCR), also known as NR3C1, is the receptor to which cortisol and other glucocorticoids bind. In humans, the GR protein is encoded by NR3C1 gene which is located on chromosome 5 (5q31) . GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. Because the receptor is expressed in several forms, it has many different effects in different parts of the body. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol (by preventing the translocation of other transcription factors from the cytosol into the nucleus) .